Biomedicine

Abstract

Background: Diabetes constitutes a worldwide epidemic, with type 2 diabetes representing the predominant form and elevating the risk of various cardiovascular complications. Furthermore, patients with Type 2 Diabetes Mellitus (T2DM) exhibit dysregulated glucose and lipid metabolism in their skeletal muscles. Aim and Objectives: This study aimed to evaluate blood levels of Creatine Kinase (CK) and Lactate Dehydrogenase (LDH) in patients with Type 2 Diabetes Mellitus (T2DM) to healthy controls, to assess their potential as indicators of metabolic stress and glycaemic control. Materials and Methods: Case-control research was conducted involving 200 participants: 100 individuals with Type 2 Diabetes Mellitus (T2DM) and 100 healthy controls. The levels of CK, LDH, and glycemic markers (HbA1c and Fasting plasma glucose) were assessed. Results: CK and LDH values were substantially higher in T2DM patients than in controls (p < 0.001). HbA1c and fasting plasma glucose showed favourable correlations with LDH (r = 0.55; p = <0.001 and r = 0.54; p = <0.001 respectively). The glycaemic parameters and CK did not significantly correlate. Conclusion: The findings imply that these enzymes could be useful indicators of metabolic stress in the treatment of diabetes. Further research is needed to determine their clinical value in tracking illness development.