Volume: 44 Issue: 1
Year: 2024, Page: 98-100, Doi: https://doi.org/10.51248/.v44i1.4113
Received: Dec. 6, 2023 Accepted: Feb. 11, 2024 Published: May 1, 2024
Introduction and Aim: Pregnancy demands vigilant fetal monitoring, yet traditional methods have limitations, leading to research on biomarkers like placental growth factor (PLGF) to enhance predictive accuracy for adverse outcomes. This investigation focuses on assessing the relationship between PLGF levels and pregnancy outcomes in women with suspected preeclampsia.
Materials and Methods: A simple longitudinal design was employed, following pregnant women with suspected preeclampsia from enrollment until delivery. The study included 160 subjects, and their characteristics were recorded at admission. PLGF levels were measured, and pregnancy outcomes were assessed.
Results: Among the study population, the distribution of pregnancies showed that 45.62% were in the first pregnancy, 40% in the second pregnancy, 11.85% in the third pregnancy, and 2.5% in the fifth pregnancy. The highest PLGF levels were observed in the fifth pregnancy group.Analysis revealed that subjects with NICU admission had a lower mean PLGF value compared to those without NICU admission. Among subjects with low PLGF levels, the mean baby weight was lower by approximately 5.3% when match up to those with normal PLGF levels.Regarding blood pressure, subjects with decreased PLGF levels had a higher mean systolic blood pressure in contrast to those with normal PLGF levels.
Conclusion: Lower PLGF levels were associated with NICU admission, lower baby weight, and higher systolic blood pressure in women with suspected preeclampsia. These findings suggest that PLGF levels may have implications for pregnancy outcomes. Additional investigation with expanded sample sizes is necessary to authenticate these discoveries and look into the clinical relevance of PLGF in understanding and addressing preeclampsia.
Keywords: Biomarker; preeclampsia; PLGF.
1. Grimes, D. A., Peipert, J.F. Electronic fetal monitoring as a public health screening program: The arithmetic of failure. Obstet Gynecol. 2010;116:1397.
2. Maglione, D., Guerriero, V., Viglietto, G., Ferraro, M.G., Aprelikova, O., Alitalo, K., et al., Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PLGF), are transcribed from a single gene of chromosome 14. Oncogene. 1993;8:925-931.
3. Khaliq, A., Li, X.F., Shams, M., Sisi, P., Acevedo, C.A., Whittle, M.J., et al., Localisation of placenta growth factor (PIGF) in human term placenta. Growth Factors. 1996;13: 243-250.
4. Vuorela, P., Hatva, E., Lymboussaki, A., Kaipainen, A., Joukov, V., Persico, M.G., et al., Expression of vascular endothelial growth factor and placenta growth factor in human placenta. Biol Reprod. 1997;56:489-494.
5. Benton, S.J., McCowan, L.M., Heazell, A.E., Grynspan, D., Hutcheon, J.A., Senger, C., et al., Placental growth factor as a marker of fetal growth restriction caused by placental dysfunction. Placenta. 2016;42:1-8.
6. Shinar, S., Tigert, M., Agrawal, S., Parks, W.A., John, C. Placental growth factor as a diagnostic tool for placental mediated fetal growth restriction. Pregnancy Hypertension. 2021;25:123-128.
7. Anderson, N., De Laat, M., Benton, S., Von Dadelszen, P., McCowan, L. Placental growth factor as an indicator of fetal growth restriction in late onset small for gestational age pregnancies. Australian and New Zealand Journal of Obstetrics and Gynaecology.2 019; 59(1):89-95.
8. Chappell, L.C., Duckworth, S., Seed, P.T., Griffin, M., Myers, J., Mackillop, L., et al., Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study. Circulation.2013;128:2121-2131.
9. Cerdeira, A.S., Agrawal, S., Staff, A.C., Redman, C.W., Vatish, M. Angiogenic factors: potential to change clinical practice in pre-eclampsia? BJOG. 2018;125:1389-1395.
10. Kingdom, J., Huppertz, B., Seaward, G., Kaufmann, P. Development of the placental villous tree and its consequences for fetal growth. Eur J Obstet Gynecol Reprod Biol. 2000; 92:35-43.
11. Miranda, M.L., Edwards, S.E., Myers, E.R. Adverse birth outcomes among nulliparous vs. multiparous women. Public Health Reports. 2011;126(6):797-805.
12. Lin, L., Lu, C., Chen, W., Li, C., Guo, V.Y. Parity and the risks of adverse birth outcomes: a retrospective study among Chinese. BMC Pregnancy and Childbirth. 2021;21(1):1-1.
13. Sherrell, H., Dunn, L., Clifton, V., Kumar, S. Systematic review of maternal placental growth factor levels in late pregnancy as a predictor of adverse intrapartum and perinatal outcomes. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2018 ;225:26-34.
14. McLaughlin, K., Snelgrove, J.W., Audette, M.C., Syed, A., Hobson, S.R., Windrim, R.C., et al., PLGF (placental growth factor) testing in clinical practice: evidence from a Canadian tertiary maternity referral center. Hypertension. 2021;77(6): 2057-2065.
15. Poon, L.C., Zaragoza, E., Akolekar, R., Anagnostopoulos, E., Nicolaides, K.H. Maternal serum placental growth factor (PlGF) in small for gestational age pregnancy at 11+ 0 to 13+ 6 weeks of gestation. Prenatal Diagnosis. Published in Affiliation with the International Society for Prenatal Diagnosis. 2008;28(12):1110-1115.
16. Guo, Q., Feng, P., Yu, Q., Zhu, W., Hu, H., Chen, X., et al., Associations of systolic blood pressure trajectories during pregnancy and risk of adverse perinatal outcomes. Hypertension Research. 2020; 43(3):227-234.
17. Teng, H., Wang, Y., Han, B., Liu, J., Cao, Y., Wang, J., et al., Gestational systolic blood pressure trajectories and risk of adverse maternal and perinatal outcomes in Chinese women. BMC Pregnancy Childbirth. 2021;21:155.
18. Iwama, N., Oba, M.S., Satoh, M., Ohkubo, T., Ishikuro, M., Obara, T., et al., Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study. Hypertens Res. 2020;43:550-559.
19. Troisi, R., Braekke, K., Harsem, N.K., Hyer, M., Hoover, R.N., Staff, A.C. Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies. American Journal of Obstetrics and Gynecology. 2008;199(6):653.e1- 653.10.
Nidhita M.N, Geetha Bhaktha, Prashanth S. Exploring the association between PLGF and pregnancy outcomes. Biomedicine: 2024; 44(1): 96-100.